For most of us in the veterinary field, radiation therapy is a mysterious treatment that occurs elsewhere or it is a modality that a family member or friend underwent. However, because it is so effective in treating people with cancer (and with the guidance of Dr. Google), more and more clients are asking about the use of this treatment in their pets. For many of us, we really haven’t been trained on how to discuss this treatment option with clients. So, I wanted to go over some of the nuts and bolts of what clients can expect when choosing radiation therapy for their pet. A number of parameters are evaluated to determine if radiation therapy can benefit a patient and what course of radiation therapy is most appropriate. These variables can include: expected outcome, tumor responsiveness, tumor location, presence of microscopic versus macroscopic disease, machine and software capability, and if concurrent or follow-up treatments are planned.

So what is radiation therapy and how does it work?
Lin Ac in MotionAt its most basic, radiation therapy involves repeatedly subjecting a tumor to a beam of high energy x-rays over a number of days or weeks. Radiation works by damaging the DNA of affected cells, leading to cell death. Because radiation is not selective about healthy or neoplastic cells, the goal is to target as many tumor cells as possible with this high energy radiation while avoiding damage to the normal surrounding tissue. So, how do we avoid damage to healthy cells?

“Precision, Precision, Precision” – Treatment Planning:

radiation treatment planning for petsUsing live video communications, our medical oncologists and surgeons consult with our radiation oncologist, Dr. William Ratterree, to determine a treatment plan for each patient’s tumor. The following steps outline the planning process.

• In order to define the extent and borders of the tumor we typically begin the process with a CT scan.
• Images from the CT scan are then loaded into treatment planning software by our radiation oncologist and a 3D model of the tumor is generated to determine the exact boundaries and depth of the tumor.
• Once this model has been created the software is also used to determine the strength and shape of the radiation beam or beams (if multiple are needed) that we need to best penetrate the entire tumor while sparing surrounding tissue as much as possible. Occasionally, for superficial tumors, we will not need to do a CT and the tumor can be “hand-planned” from physical measurements and radiographs. Once the plan is completed it is uploaded into the linear accelerator.
• When the exact boundaries of the treatment area are identified, hair will be shaved within this boundary. This area will be marked with a long-lasting ink to show exactly where the radiation will be delivered and this ink will remain on the skin throughout the entire treatment period.
• The linear accelerator sits in a concrete vault and generates and aims the high energy radiation beams based on the treatment plan loaded into it. Correct patient positioning is critical and multiple lasers are used to accurately match up patient position with the radiation beam. While the actual treatments are relatively short all patients must be placed under anesthesia. The first day is longest due to initial set up time, but most radiation treatment sessions are about 20-30 minutes long.

Different tumors – different types of plans:

Radiation therapy is a very adaptable form of therapy and no two treatment plans are alike. However, in broad terms, we have two main categories of treatment plans- definitive and palliative radiation.

 

Definitive
• These protocols are utilized in cases where a cure is a possibility and/or long-term survival is probable.
• Some common examples of tumors treated with definitive therapy include cases of incomplete or narrowly excised tumors like mast cell tumors and sarcomas (soft tissue sarcomas and injection site sarcomas), nasal tumors, and pituitary tumors.
• With these protocols the dose per treatment is lower, but a higher number of treatments are used- typically 16 -19 total treatments (about 3.5 weeks total treatment time). This is to reduce the risk of long-term effects on the adjacent normal tissues that cannot be avoided during treatment.

The most common client concerns are side effects, anesthesia risks, and cost.

Side Effects
Erythema leg side effectSide effects of radiation therapy are dependent on the course of radiation applied, location, and size of the radiation treatment area. Tumor response is closely monitored by our oncology team during and after treatments to optimally deal with any problems that may arise. There are two types of side effects:

• Acute side effects occur in tissues that have a normal rapid cell turnover, like epithelial linings (skin, mucous membranes, GI tract), and generally start during the second half of therapy and last for 1-2 weeks after therapy is complete.
• Late side effects occur in tissues where cells divide slowly and infrequently, such as bone and nervous tissue. These side effects do not generally occur until 6 months to 1 year after completion when the cells attempt to divide but instead die due to DNA damage. For these reasons, late side effects do not typically heal and can cause significant issues. Preventative measures to avoid these effects are very important, especially in patients where long term survival is possible. These preventative measures include reducing patient movement during the procedure by using positioning devices and creating radiation plans that target tumor tissue while avoiding as much normal tissue as possible.

radation therapy side effects chart

 

 

Anesthesia
anesthesia with radiation therapyTailoring sedation and anesthesia protocols to the needs of the patient minimizes anesthesia risks. All patients have an IV catheter in place, receive fluids during anesthesia and are monitored by a licensed veterinary technician (LVT). While the majority of our patients are older, they generally tolerate the short anesthetic episodes. Each treatment takes about 20-30 minutes after the initial set-up day.

Cost
Delivering the news to a client that their beloved family pet has cancer is never easy. In addition, discussing treatment options and cost can be just as difficult and escalate an already stressful situation. Will their pet need surgery, chemotherapy, and/or radiation to treat the tumor? These questions make it tough for you to provide an accurate estimate and can potentially leave clients feeling overwhelmed and helpless. All treatment plans are unique to each patient and during a consultation our oncologists can provide your client with an accurate estimate. As always, please do not hesitate to call me or Dr. Fulmer so we can guide you with potential treatment recommendations and cost.

Quick Facts:

-Patients are not radioactive after RT

-Veterinary patients do not generally have systemic illness after RT

-Anesthesia is quick and only a light plane is needed so that patients recover quickly

-Side effects do occur during therapy, however they heal within a couple of weeks with supportive care.

dog completing radiation treatment at upstate vetWhile radiation therapy is an involved modality it also an extremely effective treatment for many of our veterinary tumors. Should you have any patients who you feel might benefit from radiation in the management of their tumor feel free to reach out to us here and we will be happy to help you with making treatment decisions and recommendations.

Good review articles to consider for more information regarding RT are listed below:

Veterinary radiation therapy: review and current state of the art. McEntee MC. Journal of American Animal Hospital Association 2006;42(2):94-109

Radiation therapy for the treatment of tumours in small companion animals. Moore AS. Veterinary Journal 2002;164(3):176-87